Water → 1-(5-Methyl-2-pyridinyl)-3-(tetrahydro-1-methyl-4-oxo-1H-imidazol-2-ylidene) urea

HRID 904155ノート

反応式

HRID 904155 の反応式
[CH3:1][N:2]1[CH2:6][C:5](=[O:7])[NH:4][C:3]1=[N:8][C:9](=[O:11])O.[NH2:12][C:13]1[CH:18]=[CH:17][C:16]([CH3:19])=[CH:15][N:14]=1.O>CN(C=O)C>[CH3:19][C:16]1[CH:17]=[CH:18][C:13]([NH:12][C:9]([N:8]=[C:3]2[NH:4][C:5](=[O:7])[CH2:6][N:2]2[CH3:1])=[O:11])=[N:14][CH:15]=1

参加物

5

反応物 3

HCID 962WaterHCID 153482-Amino-5-methylpyridineHCID 136469822tetrahydro-1-methyl-4-oxo-1H-imidazol-2-ylidene carbamic acid

生成物 1

HCID 1361291791-(5-Methyl-2-pyridinyl)-3-(tetrahydro-1-methyl-4-oxo-1H-imidazol-2-ylidene) urea収率 76.9%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
70 °C

実験手順

A mixture of 2.33 g (10.0 mM) of the phenyl carbamate 8 and 1.08 g (10.0 mM) of 2-amino-5-methylpyridine in 9 ml of anhydrous DMF was stirred at 70° C. for 2 hrs., cooled and poured into water with stirriang. The resulting precipitate was collected, washed with water and then acetone to give 1.9 g of the above urea as a pale yellow solid, m.p. 227° C. (dec.).

後処理

  1. temperature, cooled
  2. customThe resulting precipitate was collected
  3. washwashed with water

出典と根拠

ORDレコード
ord-23b90af7a3df401d9ad525cd41cbdf62
出典データセット
uspto-grants-1980_10
特許番号
US04230713

反応ノート

読み込み中…