Water → 1-(2-Methoxy-5-pyridinyl)-3-(tetrahydro-1-methyl-4-oxo-1H-imidazol-2-ylidene) urea
反応式
[CH3:1][N:2]1[CH2:6][C:5](=[O:7])[NH:4][C:3]1=[N:8][C:9](=[O:11])O.[NH2:12][C:13]1[CH:14]=[CH:15][C:16]([O:19][CH3:20])=[N:17][CH:18]=1.O>CN(C=O)C>[CH3:20][O:19][C:16]1[CH:15]=[CH:14][C:13]([NH:12][C:9]([N:8]=[C:3]2[NH:4][C:5](=[O:7])[CH2:6][N:2]2[CH3:1])=[O:11])=[CH:18][N:17]=1参加物
5
実験手順
A mixture of 2.33 g (10.0 mM) of phenyl carbamate 8 and 1.24 g. (10.0 mM) of 5-amino-2-methoxypyridine in 9 ml of anhydrous DMF was heated at 70° C. for 6 hrs., cooled, and poured into 40 ml of water. On cooling in ice, crystals precipitated from the aqueous solution and these were collected and recrystallized from methanol to give 0.5 g of the above urea as pale yellow needles, m.p. 175°-176° C.
後処理
- temperature, cooled
- temperatureOn cooling in ice
- customcrystals precipitated from the aqueous solution
- customthese were collected
- customrecrystallized from methanol
出典と根拠
- ORDレコード
- ord-33826941d3ee458cba3700031ad4985f
- 出典データセット
- uspto-grants-1980_10
- 特許番号
- US04230713
反応ノート
読み込み中…