関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | creatinine | HCID 588 | — |
| 反応物 | Water | HCID 962 | — |
| 反応物 | 2-Isocyanato-5-methylthiophene | HCID 11629619 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 1-(5-Methyl-2-thienyl)-3-(tetrahydro-1-methyl-4-oxo-1H-imidazol-2-ylidene) urea | HCID 136129176 | 74.7% |
反応手順
To 1.44 g (12.8 mM) of creatinine in 25 ml of anhydrous DMF was added with stirring 1.78 g (12.8 mM) of 5-methyl-2-thienyl isocyanate in 12 ml of toluene. After 6 hrs. at 60° C., the mixture was cooled, poured into 100 ml of water and filtered. The collected solid was recrystallized twice from ethyl acetate to give 2.4 g of the above urea as a yellow-orange solid, m.p. 207°-209° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04230713 |
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| 出典データセット | uspto-grants-1980_10 |
|---|
| ORD ID | ord-d5b88829eb5b4d9cb5be609cfccd79fd |
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| 出典メモ | uspto-grants-1980_10 |
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