関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | creatinine | HCID 588 | — |
| 反応物 | Water | HCID 962 | — |
| 反応物 | 2-Isocyanato-3-methylthiophene | HCID 23361759 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 1-(3-Methyl-2-thienyl)-3-(tetrahydro-1-methyl-4-oxo-1H-imidazol-2-ylidene) urea | HCID 136098953 | 17.9% |
反応手順
To a stirred suspension of 3.0 g (26.0 mM) of creatinine in 50 ml of anhydrous DMF was added dropwise a solution of 3.7 g (26 mM) of 3-methyl-2-thienyl isocyanate in 35 ml of toluene. After stirring at 90° C. for 6 hrs., the reaction mixture was cooled and poured into 100 ml of water. The separated solid was collected, washed with water and recrystallized from ethyl acetate to give 1.2 g of the above urea as a grey-white solid, m.p. 201°-202° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04230713 |
|---|
| 出典データセット | uspto-grants-1980_10 |
|---|
| ORD ID | ord-ff64be56b72740abae71f626cc372c44 |
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| 出典メモ | uspto-grants-1980_10 |
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