Sodium Cyanide → 12-Hydroxydodecanenitrile

HRID 904240ノート

反応式

HRID 904240 の反応式
Br[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][OH:13].[C-:14]#[N:15].[Na+]>CN(C)C=O>[OH:13][CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2][C:14]#[N:15]

参加物

4

反応物 2

HCID 8929Sodium CyanideHCID 7416311-Bromo-1-undecanol

生成物 1

HCID 1033034812-Hydroxydodecanenitrile

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

A solution 4.6 g. of 11-bromoundecanol and 1.6 g. of sodium cyanide in 40 ml. of dimethylformamide is heated at 80° C. for 18 hours, cooled, and poured into ice-water. The mixture is extracted with methylene chloride and the extract is dried over anhydrous magnesium sulfate. Evaporation of the solution affords 12-hydroxydodecanonitrile as a yellow oil.

後処理

  1. temperaturecooled
  2. extractionThe mixture is extracted with methylene chloride
  3. dry with materialthe extract is dried over anhydrous magnesium sulfate
  4. customEvaporation of the solution

出典と根拠

ORDレコード
ord-af4d2d2762314fcc986794205f24620b
出典データセット
uspto-grants-1980_10
特許番号
US04230628

反応ノート

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