Glycerol → 2,3-Dihydroxypropyl 4-(15-carbomethoxypentadecylamino)benzoate

HRID 904254ノート

反応式

HRID 904254 の反応式
[C:1]([CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][NH:20][C:21]1[CH:29]=[CH:28][C:24]([C:25]([OH:27])=[O:26])=[CH:23][CH:22]=1)([O:3][CH3:4])=[O:2].[OH:30][CH2:31][CH:32]([CH2:34]O)[OH:33].B(F)(F)F.CCOCC>C1(C)C=CC=CC=1>[C:1]([CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][NH:20][C:21]1[CH:22]=[CH:23][C:24]([C:25]([O:27][CH2:34][CH:32]([OH:33])[CH2:31][OH:30])=[O:26])=[CH:28][CH:29]=1)([O:3][CH3:4])=[O:2]

参加物

5

反応物 3

HCID 753GlycerolHCID 8000Boron trifluoride etherate2 回HCID 12898273p-(15-Carbomethoxypentadecylamino)benzoic acid

生成物 1

HCID 211632452,3-Dihydroxypropyl 4-(15-carbomethoxypentadecylamino)benzoate

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

A solution of 11.8 g. of 4-(15-carbomethoxypentadecylamino)benzoic acid, 1.00 g. of glycerol, and 5.35 ml. of boron trifluoride etherate in 200 ml. of toluene is stirred under reflux for 4 hours. The solution is treated with an additional 5.35 ml. of boron trifluoride etherate and refluxing is continued for 120 hours. Dilution with water and methylene chloride followed by filtration affords 2,3-dihydroxypropyl 4-(15-carbomethoxypentadecylamino)benzoate as a white solid.

後処理

  1. temperatureunder reflux for 4 hours
  2. additionThe solution is treated with an additional 5.35 ml
  3. filtrationDilution with water and methylene chloride followed by filtration

出典と根拠

ORDレコード
ord-7d1b9ef4addf48f2b998de9efbd2272e
出典データセット
uspto-grants-1980_10
特許番号
US04230628

反応ノート

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