3-(Dimethylamino)propyl chloride hydrochloride → 4-(3'-Dimethylaminopropoxy)-3-phenyl-coumarin
反応式
[C:1]1([C:7]2[C:8](=[O:18])[O:9][C:10]3[C:15]([C:16]=2[OH:17])=[CH:14][CH:13]=[CH:12][CH:11]=3)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl.[CH3:20][N:21]([CH3:26])[CH2:22][CH2:23][CH2:24]Cl>>[CH3:20][N:21]([CH3:26])[CH2:22][CH2:23][CH2:24][O:17][C:16]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[O:9][C:8](=[O:18])[C:7]=1[C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1参加物
3
実験手順
By treating 10 g. (0.042 mol) of 3-phenyl-4-hydroxy-coumarin with 87 g. (0.055 mol) of 3-dimethylamino-1-chloropropane hydrochloride as described in Example 1, there are obtained 8.1 g. of a yellow oil which cannot be crystallised. Yield 59% (theoretical yield 13.6 g.).
後処理
- additionBy treating 10 g
- customare obtained 8.1 g
- customof a yellow oil which cannot be crystallised