N-(1,1-Dimethylethyl)benzenemethanamine → HCID 20458608、化合物

HRID 904663

反応式

HRID 904663 の反応式
C(NC(OC1C=C(C(=O)C[Br:21])C=C(OC(=O)NCC)C=1)=O)C.[CH2:23]([NH:30][C:31]([CH3:34])([CH3:33])[CH3:32])[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1>CC(C)=O>[BrH:21].[CH2:23]([NH:30][C:31]([CH3:34])([CH3:33])[CH3:32])[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1

参加物

4

反応物 2

HCID 76908N-(1,1-Dimethylethyl)benzenemethanamineHCID 204586013',5'-bis-(N-ethylcarbamoyloxy)-2-bromo acetophenone

生成物 1

HCID 20458608HCID 20458608、化合物収率 78.3%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

To a solution of 8.0 g of 3',5'-bis-(N-ethylcarbamoyloxy)-2-bromo acetophenone in 100 ml of acetone was added 7.0 g of N-benzyl-t-butylamine. The mixture was refluxed for 18 hours. The 4.1 g of N-benzyl-t-butylamine hydrobromide formed and precipitated during the reaction was filtered off and the filtrate was acidified with conc HCl. The filtrate was now evaporated to dryness and the title compound was isolated by column chromatography on Silica gel 60 using 1) CHCl3 /ethanol (2:1), 2) ethanol as eluants. The title compound was eluted in the ethanol fraction and recrystallized from ethanol/diethylether. The identity of the product was confirmed with NMR.

後処理

  1. temperatureThe mixture was refluxed for 18 hours

出典と根拠

ORDレコード
ord-2c26adbca5da4cac866dbebb3bdc88d7
出典データセット
uspto-grants-1983_12
特許番号
US04419364

関連ノート

読み込み中…