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Pyridine → Piperidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Pyridine | HCID 1049 | — |
| 反応物 | Acetonitrile | HCID 6342 | — |
| 反応物 | Nitromethane | HCID 6375 | — |
| 反応物 | Benzenepropanenitrile, 4-amino-beta-oxo- | HCID 96920 | — |
| 溶媒 | Isopropanol | HCID 3776 | — |
| 生成物 | Piperidine | HCID 8082 | — |
| 生成物 | Dabco | HCID 9237 | — |
| 生成物 | 1,1,3,3-Tetramethylguanidine | HCID 66460 | — |
反応手順
In accordance with the second procedure, the 4-alkanesulfonaminobenzoylacetonitrile is first prepared by reaction of an alkanesulfonylchloride with 4-amino-benzoylacetonitrile at room temperature in dry pyridine. This product is in turn reacted with a dialkylaminobenzaldehyde at reflux temperature in isopropyl alcohol, acetonitrile, nitromethane, or a similar polar solvent and in the presence of a catalytic amount of piperidine, or another catalyst of comparable basicity such as tetramethylguanidine or triethylenediamine, to yield the desired dye.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04420555 |
| 出典データセット | uspto-grants-1983_12 |
| ORD ID | ord-f9c4427952c3423b91e2d1a258b32f99 |
| 出典メモ | uspto-grants-1983_12 |