N,N-Dimethylethylenediamine → 3-Pyridinecarbonitrile, 2-[[2-(dimethylamino)ethyl]amino]-4,6-dimethyl-

反応式

Cl[C:2]1[C:7]([C:8]#[N:9])=[C:6]([CH3:10])[CH:5]=[C:4]([CH3:11])[N:3]=1.[CH3:12][N:13]([CH3:17])[CH2:14][CH2:15][NH2:16]>>[CH3:12][N:13]([CH3:17])[CH2:14][CH2:15][NH:16][C:2]1[C:7]([C:8]#[N:9])=[C:6]([CH3:10])[CH:5]=[C:4]([CH3:11])[N:3]=1

参加物

反応物 2

HCID 66053N,N-Dimethylethylenediamine

HCID 2232612-Chloro-4,6-dimethyl-3-pyridinecarbonitrile

生成物 1

HCID 34118773-Pyridinecarbonitrile, 2-[[2-(dimethylamino)ethyl]amino]-4,6-dimethyl-

反応条件

温度: 105 °C

実験手順

A mixture of 2-chloro-3-cyano-4,6-dimethylpyridine (10.0 g, 60 mmol) and N,N-dimethyl-1,2-diaminoethane (10.6 g, 120 mmol) is heated at 105° C. for 20 hours. Added benzene, evaporated to dryness, dissolved residue in water, made basic with sodium carbonate and extract product into methylene chloride, dried and evaporated to give 13.4 g of oily title A product.

後処理

customAdded benzene, evaporated to dryness
dissolutiondissolved residue in water
extractionextract product into methylene chloride
customdried
customevaporated
customto give 13.4 g of oily title A product

出典と根拠

ORDレコード: ord-ee2be81bdfd74efc91c78ad5d195ad40
出典データセット: uspto-grants-1983_12
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04420615

反応ノート

読み込み中…

参加物