(2-{[2-(Dimethylamino)ethyl]amino}-4,6-dimethylpyridin-3-yl)methanol → HCID 20477991、化合物
反応式
[CH3:1][N:2]([CH3:16])[CH2:3][CH2:4][NH:5][C:6]1[C:11]([CH2:12][OH:13])=[C:10]([CH3:14])[CH:9]=[C:8]([CH3:15])[N:7]=1>C(Cl)Cl.[O-2].[O-2].[Mn+4]>[CH3:1][N:2]([CH3:16])[CH2:3][CH2:4][NH:5][C:6]1[N:7]=[C:8]([CH3:15])[CH:9]=[C:10]([CH3:14])[C:11]=1[CH:12]=[O:13]参加物
4
実験手順
A solution of crude 2-(2-dimethylaminoethylamino)-3-hydroxymethyl-4,6-dimethylpyridine (15.0 g, 67 mmol) in methylene chloride (300 ml) containing a suspension of activated manganese dioxide (35 g) is refluxed for 5 hours. The solution is filtered hot and the manganese dioxide re-extracted with hot methylene chloride. The combined extracts are filtered through charcoal and evaporated to give 12.0 g of crude title D product.
後処理
- temperatureis refluxed for 5 hours
- filtrationThe solution is filtered hot
- extractionthe manganese dioxide re-extracted with hot methylene chloride
- filtrationThe combined extracts are filtered through charcoal
- customevaporated
- customto give 12.0 g of crude title D product
出典と根拠
- ORDレコード
- ord-459c9d1443384610b59d84eaa51a49ad
- 出典データセット
- uspto-grants-1983_12
- 特許番号
- US04420615
反応ノート
読み込み中…