Dimethyl Sulfate → N-(alpha-Cyano-3-phenoxybenzyl)-N,N,N-trimethylammonium methylsulfate

HRID 904901ノート

反応式

HRID 904901 の反応式
[S:1]([O:6]C)([O:4][CH3:5])(=[O:3])=[O:2].[CH3:8][N:9]([CH3:26])[CH:10]([C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([O:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[CH:14]=1)[C:11]#[N:12]>CC(CC)=O>[CH3:5][O:4][S:1]([O-:6])(=[O:3])=[O:2].[C:11]([CH:10]([N+:9]([CH3:5])([CH3:26])[CH3:8])[C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([O:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[CH:14]=1)#[N:12]

参加物

4

反応物 2

HCID 6497Dimethyl SulfateHCID 13565187alpha-(Dimethylamino)-3-phenoxybenzeneacetonitrile

生成物 1

HCID 13565188N-(alpha-Cyano-3-phenoxybenzyl)-N,N,N-trimethylammonium methylsulfate収率 203.7%

試薬・触媒・溶媒 1

HCID 6569Methyl Ethyl Ketone溶媒

実験手順

Dimethyl sulfate (2.52 g) was added to a solution of α-(dimethylamino)-3-phenoxybenzeneacetonitrile (5.2 g) in ethyl methyl ketone (40 ml) and the mixture was stirred overnight at ambient temperature. The solvent was removed by distillation under reduced pressure to give the title compound (7.7 g) as a golden oil. Proton magnetic resonance spectrum (CDCl3 ; δ in ppm): 3.4 (9H, s, N(CH3)3); 3.65 (3H, s, CH3SO4); 6.7 (1H, s, CH); 7.0-7.7 (9H, m, aromatic protons).

後処理

  1. customThe solvent was removed by distillation under reduced pressure

出典と根拠

ORDレコード
ord-392d9d74b82e46f1983ac4eda1fce2d4
出典データセット
uspto-grants-1983_12
特許番号
US04420614

反応ノート

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