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Dicyclohexylcarbodiimide → Z-Glu(OBzl)-Val-Thr(But)-OBut

HRID 904951
ノート
印刷プレビュー

反応式

HRID 904951 の反応式
[NH2:1][C@H:2]([C:6]([NH:8][C@H:9]([C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[C@@H:10]([CH3:16])[O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:7])[CH:3]([CH3:5])[CH3:4].Cl.[CH:25]1[CH:30]=[CH:29][C:28]([CH2:31][O:32][C:33]([CH2:35][CH2:36][C@H:37]([NH:41][C:42]([O:44][CH2:45][C:46]2[CH:51]=[CH:50][CH:49]=[CH:48][CH:47]=2)=[O:43])[C:38](O)=[O:39])=[O:34])=[CH:27][CH:26]=1.C1CCC(N=C=NC2CCCCC2)CC1.C1C=CC2N(O)N=NC=2C=1>CN(C)C=O>[NH:41]([C:42]([O:44][CH2:45][C:46]1[CH:51]=[CH:50][CH:49]=[CH:48][CH:47]=1)=[O:43])[C@H:37]([C:38]([NH:1][C@H:2]([C:6]([NH:8][C@H:9]([C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[C@@H:10]([CH3:16])[O:11][C:12]([CH3:13])([CH3:14])[CH3:15])=[O:7])[CH:3]([CH3:5])[CH3:4])=[O:39])[CH2:36][CH2:35][C:33](=[O:34])[O:32][CH2:31][C:28]1[CH:29]=[CH:30][CH:25]=[CH:26][CH:27]=1
参加物実験手順後処理出典と根拠反応ノート

参加物

6

反応物 4

HCID 10868DicyclohexylcarbodiimideHCID 757711-HydroxybenzotriazoleHCID 30498605-(Phenylmethyl) hydrogen N-((phenylmethoxy)carbonyl)-L-glutamateHCID 131713270H-Val-Thr(But)-OBut.HCl

生成物 1

HCID 12944649Z-Glu(OBzl)-Val-Thr(But)-OBut

試薬・触媒・溶媒 1

HCID 6228
Dimethylformamide
溶媒

実験手順

25.7 g of H-Val-Thr(But)-OBut.HCl are reacted, in 250 ml of dimethylformamide, with 26.0 g of Z-Glu-(OBzl)-OH and 15 g of DCC in the presence of 9.5 g of HOBt. After stirring for 6 hours the mixture is filtered and the filtrate is evaporated to dryness in vacuo. The residue is taken up in ethyl acetate, the solution is washed as described under (A) and, after drying and evaporating off the solvent, 37.3 g of the title compound are obtained with a melting point of 140°-144° (decomposition). Elementary analysis correct (C, H and N).

後処理

  1. filtrationis filtered
  2. customthe filtrate is evaporated to dryness in vacuo
  3. washthe solution is washed
  4. customafter drying
  5. customevaporating off the solvent, 37.3 g of the title compound
  6. customare obtained with a melting point of 140°-144° (decomposition)

出典と根拠

ORDレコード
ord-667fbe6c43d94e98b5d1aa7159601041
出典データセット
uspto-grants-1983_12
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US04420424

反応ノート

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