5-(Phenylmethyl) hydrogen N-((phenylmethoxy)carbonyl)-L-glutamate → H-Glu-Ile-Val-OBut

反応式

[NH:1](C(OCC1C=CC=CC=1)=O)[C@H:2]([C:15](O)=[O:16])[CH2:3][CH2:4][C:5](=[O:14])[O:6]CC1C=CC=CC=1.[NH2:28][C@H:29]([C:34]([NH:36][C@H:37]([C:41]([O:43][C:44]([CH3:47])([CH3:46])[CH3:45])=[O:42])[CH:38]([CH3:40])[CH3:39])=[O:35])[C@H:30]([CH2:32][CH3:33])[CH3:31].Cl>>[NH2:1][C@H:2]([C:15]([NH:28][C@H:29]([C:34]([NH:36][C@H:37]([C:41]([O:43][C:44]([CH3:47])([CH3:45])[CH3:46])=[O:42])[CH:38]([CH3:39])[CH3:40])=[O:35])[C@H:30]([CH2:32][CH3:33])[CH3:31])=[O:16])[CH2:3][CH2:4][C:5](=[O:6])[OH:14]

参加物

反応物 2

HCID 30498605-(Phenylmethyl) hydrogen N-((phenylmethoxy)carbonyl)-L-glutamate

HCID 131713275H-Ile-Val-OBut.HCl

生成物 1

HCID 131713274H-Glu-Ile-Val-OBut

実験手順

37 g of Z-Glu(OBzl)OH are reacted with 32 g of H-Ile-Val-OBut.HCl and the product is worked up, as described in Example 21 (C). After catalytic hydrogenation the compound is a single substance according to chromatography.

出典と根拠

ORDレコード: ord-2b38ff64bcec425db1ead604e25ef8c3
出典データセット: uspto-grants-1983_12
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04420424

反応ノート

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