Phosgene → HCID 20477495、化合物

HRID 905108ノート

反応式

HRID 905108 の反応式
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[NH:8][CH2:7][CH2:6][C:5]2=[O:12].[C:13](Cl)([Cl:15])=[O:14]>O1CCOCC1>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]([C:13]([Cl:15])=[O:14])[CH2:7][CH2:6][C:5]2=[O:12]

参加物

4

反応物 2

HCID 6371PhosgeneHCID 7594476-Bromo-1,2,3,4-tetrahydroquinolin-4-one

生成物 1

HCID 20477495HCID 20477495、化合物

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

45.2 Parts of 6-bromo-4-oxo-1,2,3,4-tetrahydroquinoline and 200 parts of dioxane were mixed, and 39.4 parts of phosgene was introduced to the stirred mixture while the temperature was maintained at 20°-25° C. over about 30 minutes. After the introduction, the reaction was effected at 40°-45° C. for 2.5 hours, and thereafter the mixture was treated as in Example 37 (a) to obtain 55.9 parts of 6-bromo-4-oxo-1-chloroformyl-1,2,3,4-tetrahydroquinoline.

後処理

  1. temperaturewas maintained at 20°-25° C. over about 30 minutes

出典と根拠

ORDレコード
ord-8b0a02192f7b4aa8a270586723668643
出典データセット
uspto-grants-1983_12
特許番号
US04421919

反応ノート

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