4-Chlorophenol → 4-Chlorophenyl 4-(8-cyclohexyloctylamino)benzoate

HRID 905273ノート

反応式

HRID 905273 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][CH:3]=1.C(N(CC)CC)C.Cl.[CH:17]1([CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][NH:31][C:32]2[CH:40]=[CH:39][C:35]([C:36](Cl)=[O:37])=[CH:34][CH:33]=2)[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]1>C(Cl)Cl>[CH:17]1([CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][NH:31][C:32]2[CH:40]=[CH:39][C:35]([C:36]([O:8][C:5]3[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=3)=[O:37])=[CH:34][CH:33]=2)[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]1

参加物

5

反応物 3

HCID 46844-ChlorophenolHCID 8471TriethylamineHCID 20475769p-(8-Cyclohexyloctyl)aminobenzoyl chloride hydrochloride

生成物 1

HCID 204758364-Chlorophenyl 4-(8-cyclohexyloctylamino)benzoate

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

To a solution of 6.4 g. 4-chlorophenol and 7.6 g. triethylamine in 500 ml. methylene chloride is added 10.4 g. 4-(8-cyclohexyloctylamino)benzoyl chloride hydrochloride in 250 ml. methylene chloride. After four hours at reflux, the solution is cooled, washed with water and dilute phosphoric acid, and dried. After passing the solution through a column of alumina, the solvent is evaporated an the residue is crystallized from diisopropyl ether.

後処理

  1. temperatureAfter four hours at reflux
  2. temperaturethe solution is cooled
  3. washwashed with water and dilute phosphoric acid
  4. customdried
  5. customthe solvent is evaporated an the residue
  6. customis crystallized from diisopropyl ether

出典と根拠

ORDレコード
ord-e23027eb14544ef0a5f2b75fae7a2471
出典データセット
uspto-grants-1983_12
特許番号
US04423051

反応ノート

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