2-{[1,1-Dimethyl-2-(2-phenoxyacetamido)ethyl]amino}-2'-chloro-3',4'-bis(benzyloxy)acetophenone hydrobromide → 1,1-Dimethyl-2-(2-phenoxyacetamido)ethylamine

HRID 905300

反応式

HRID 905300 の反応式
[BrH:1].[CH3:2][C:3]([NH:17]CC(C1C=CC(O)=C(O)C=1Cl)=O)([CH3:16])[CH2:4][NH:5][C:6](=[O:15])[CH2:7][O:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.Br.CC(N[CH2:47][C:48]([C:50]1[CH:55]=[CH:54][C:53]([O:56][CH2:57][C:58]2[CH:63]=[CH:62][CH:61]=[CH:60][CH:59]=2)=[C:52]([O:64][CH2:65][C:66]2[CH:71]=[CH:70][CH:69]=[CH:68][CH:67]=2)[C:51]=1Cl)=[O:49])(C)CNC(=O)COC1C=CC=CC=1>>[NH2:17][C:3]([CH3:16])([CH3:2])[CH2:4][NH:5][C:6](=[O:15])[CH2:7][O:8][C:9]1[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=1.[Br:1][CH2:47][C:48]([C:50]1[CH:55]=[CH:54][C:53]([O:56][CH2:57][C:58]2[CH:63]=[CH:62][CH:61]=[CH:60][CH:59]=2)=[C:52]([O:64][CH2:65][C:66]2[CH:71]=[CH:70][CH:69]=[CH:68][CH:67]=2)[CH:51]=1)=[O:49]

参加物

4

反応物 2

HCID 204467582-{[1,1-Dimethyl-2-(2-phenoxyacetamido)ethyl]amino}-2'-chloro-3',4'-bis(benzyloxy)acetophenone hydrobromideHCID 204468022-{[1,1-Dimethyl-2-(2-phenoxyacetamido)ethyl]amino}-2'-chloro-3',4'-dihydroxy acetophenone hydrobromide

生成物 2

HCID 118062741,1-Dimethyl-2-(2-phenoxyacetamido)ethylamineHCID 126818023,4-Dibenzyloxyphenacyl bromide

実験手順

The above acetophenone derivative (A) was itself prepared in 85% yield, as a solid m.p. 141°-143° C. by a similar procedure to that described for the equivalent starting material in Example 11, but from 2-{[1,1-dimethyl-2-(2-phenoxyacetamido)ethyl]amino}-2'-chloro-3',4'-bis(benzyloxy)acetophenone hydrobromide. The latter compound was itself obtained in 40% yield as a solid, m.p. 61°-63° C., from N-(2-amino-2-methylpropyl)-2-phenoxyacetamide and 2-bromo-3',4'-bis(benzyloxy)acetophenone using a procedure similar to that in Example 11.

出典と根拠

ORDレコード
ord-ebb36d08f9ca4acd92be7f997a9ed781
出典データセット
uspto-grants-1983_12
特許番号
US04423070

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