Dimethylformamide → 4-[5-(2,2-Difluoro-vinyl)-thiazol-2-yl]-piperazine-1-carboxylic acid tert-butyl ester
反応式
[Br:20][C:21]([F:22])([F:23])[Br:24].[C:25]([CH3:26])([CH3:27])([CH3:28])[O:29][C:30](=[O:31])[N:32]1[CH2:33][CH2:34][N:35]([c:38]2[s:39][c:40]([CH:43]=[O:44])[cH:41][n:42]2)[CH2:36][CH2:37]1.[CH3:45][N:46]([CH3:47])[CH:48]=[O:49].[Zn:50].[c:1]1([P:2]([c:3]2[cH:4][cH:5][cH:6][cH:7][cH:8]2)[c:9]2[cH:10][cH:11][cH:12][cH:13][cH:14]2)[cH:15][cH:16][cH:17][cH:18][cH:19]1>>[C:21]([F:22])([F:23])=[CH:43][c:40]1[s:39][c:38]([N:35]2[CH2:34][CH2:33][N:32]([C:30]([O:29][C:25]([CH3:26])([CH3:27])[CH3:28])=[O:31])[CH2:37][CH2:36]2)[n:42][cH:41]1
