Water → 2-bromo-4-nitro-6-(trifluoromethyl)aniline
反応式
[Br:1]Br.[N+:3]([C:6]1[CH:11]=[CH:10][C:9]([NH2:12])=[C:8]([C:13]([F:16])([F:15])[F:14])[CH:7]=1)([O-:5])=[O:4].O>C(O)(=O)C>[Br:1][C:10]1[CH:11]=[C:6]([N+:3]([O-:5])=[O:4])[CH:7]=[C:8]([C:13]([F:14])([F:15])[F:16])[C:9]=1[NH2:12]参加物
5
反応条件
- 温度
- 120 °C
実験手順
Bromine (0.60 mL) dissolved in acetic acid (11 mL) was added dropwise to a solution of 4-nitro-2-trifluoromethyl-phenylamine (2.4 g) in acetic acid (12 mL). The reaction mixture was heated to 120° C. for 2½ hours, poured into water (400 mL) and filtered. The collected solid was washed with water (200 mL) and dried in vacuo to furnish 3.03 g (91% yield) of the title compound as a yellow solid. 1H NMR (500 MHz, DMSO-d6): 7.08 (s, 2H), 8.23 (d, 1H), 8.51 (d, 1H).
後処理
- filtrationfiltered
- washThe collected solid was washed with water (200 mL)
- customdried in vacuo
出典と根拠
- ORDレコード
- ord-5002d1daa15c45d79ff37db84186b41a
- 出典データセット
- uspto-grants-2011_09
- 特許番号
- US08012962B2
反応ノート
読み込み中…