tert-Butyl (3-(2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)-3-hydroxypropyl)carbamate → tert-Butyl 2,4-dioxopiperidine-1-carboxylate
反応式
[C:1]([O:5][C:6](=[O:22])[NH:7][CH2:8][CH2:9][C:10](=[C:12]1C(=O)OC(C)(C)[O:14][C:13]1=O)[OH:11])([CH3:4])([CH3:3])[CH3:2]>O1CCOCC1>[C:1]([O:5][C:6]([N:7]1[CH2:8][CH2:9][C:10](=[O:11])[CH2:12][C:13]1=[O:14])=[O:22])([CH3:4])([CH3:3])[CH3:2]参加物
3
実験手順
A stirred solution of [3-(2,2-dimethyl-4,6-dioxo-[1,3]dioxin-5-ylidene)-3-hydroxy-propyl]-carbamic acid tert-butyl ester (9.2 g, 29.2 mmol) obtained from Example 41 in 180 ml of dioxane was heated to reflux for 2 hours. The mixture was evaporated under reduced pressure to give the crude product 2,4-dioxo-piperidine-1-carboxylic acid tert-butyl ester (6.4 g) as a yellow oil which was used as such.
後処理
- temperatureto reflux for 2 hours
- customThe mixture was evaporated under reduced pressure
出典と根拠
- ORDレコード
- ord-8a46994b9c6542f3940ec0f99b42ff86
- 出典データセット
- uspto-grants-2011_09
- 特許番号
- US08012966B2
反応ノート
読み込み中…