HCID 67386154、化合物 → (3R,4S)-3-Methyl-1-(methylsulfonyl)piperidin-4-amine

HRID 905934ノート

反応式

HRID 905934 の反応式
C([NH:8][CH:9]1[CH2:14][CH2:13][N:12]([S:15]([CH3:18])(=[O:17])=[O:16])[CH2:11][CH:10]1[CH3:19])C1C=CC=CC=1.Cl.C[C@H]1[C@@H](N)CCOC1>>[CH3:18][S:15]([N:12]1[CH2:13][CH2:14][C@H:9]([NH2:8])[C@H:10]([CH3:19])[CH2:11]1)(=[O:17])=[O:16]

参加物

3

反応物 2

HCID 67386154HCID 67386154、化合物HCID 126970408(3S,4S)-3-Methyltetrahydro-2H-pyran-4-amine hydrochloride

生成物 1

HCID 95778702(3R,4S)-3-Methyl-1-(methylsulfonyl)piperidin-4-amine

実験手順

Racemic cis 1-methanesulfonyl-3-methyl-piperidin-4-yl-amine was prepared in the same manner from racemic benzyl-(1-methanesulfonyl-3-methyl-piperidin-4-yl)-amine. In this instance, 1 atm H2 was used instead of 55 psi, and the HCl treatment was omitted.

出典と根拠

ORDレコード
ord-3f026960a77649f6a42a42eeeaf15813
出典データセット
uspto-grants-2011_09
特許番号
US08012974B2

反応ノート

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