Trifluoroacetic acid methylene chloride → HCID 67414694、化合物

HRID 906037ノート

反応式

HRID 906037 の反応式
[C:1]([O:4][C:5]1[CH:10]=[CH:9][C:8]([NH:11][C:12]([C:14]2[CH:19]=[CH:18][C:17]([N:20]3[CH2:25][CH2:24][N:23](C(OC(C)(C)C)=O)[CH2:22][CH2:21]3)=[CH:16][CH:15]=2)=C)=[CH:7][CH:6]=1)(=[O:3])[CH3:2].C(Cl)Cl.[C:36]([OH:42])([C:38]([F:41])([F:40])[F:39])=[O:37]>>[F:39][C:38]([F:41])([F:40])[C:36]([O-:42])=[O:37].[C:1]([O:4][C:5]1[CH:10]=[CH:9][C:8]([NH:11][C:12]([C:14]2[CH:19]=[CH:18][C:17]([N:20]3[CH2:25][CH2:24][NH2+:23][CH2:22][CH2:21]3)=[CH:16][CH:15]=2)=[O:37])=[CH:7][CH:6]=1)(=[O:3])[CH3:2]

参加物

3

反応物 2

HCID 21863450Trifluoroacetic acid methylene chlorideHCID 57439883HCID 57439883、化合物

生成物 1

HCID 67414694HCID 67414694、化合物収率 95%

実験手順

tert-butyl 4-[4-(1-{[4-(acetyloxy)phenyl]amino}vinyl)phenyl]piperazine-1-carboxylate (0.1 M) in a solution of DCM/TFA (2/3) was stirred at RT for 30 min. The organic solvent was evaporated in vacuo and the crude residue was scratched with Et2O. The resultant white solid precipitate was filtered off to afford the title compound (95%); MS (ES+) m/z 339 (M+H)+

後処理

  1. customThe organic solvent was evaporated in vacuo
  2. filtrationThe resultant white solid precipitate was filtered off

出典と根拠

ORDレコード
ord-a9eb63e8e30246309e29765be4102858
出典データセット
uspto-grants-2011_09
特許番号
US08012982B2

反応ノート

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