Methanol → methyl 2-bromo-3-methoxybenzoate

HRID 906107ノート

反応式

HRID 906107 の反応式
[Br:1][C:2]1[C:10]([O:11][CH3:12])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].S(=O)(=O)(O)O.[CH3:18]O>>[Br:1][C:2]1[C:10]([O:11][CH3:12])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([O:6][CH3:18])=[O:5]

参加物

4

反応物 3

HCID 887MethanolHCID 1118Sulfuric AcidHCID 1451622-Bromo-3-methoxybenzoic acid

生成物 1

HCID 10922803methyl 2-bromo-3-methoxybenzoate収率 80%

実験手順

To a solution of 2-bromo-3-methoxybenzoic acid (718 mg, 3.11 mmol) in methanol (20 mL) was added a catalytic amount of concentrated sulfuric acid and the mixture was brought to reflux for 20 h. On cooling to room temperature, the solution was concentrated and the residue was taken into ethyl acetate and washed with water, saturated aqueous sodium bicarbonate (2×) and brine then dried over sodium sulfate. The solution was then filtered and concentrated to give methyl 2-bromo-3-methoxybenzoate (610 mg, 80%). MS (EI) for C9H9BrO3: 245 (MH+).

後処理

  1. temperatureto reflux for 20 h
  2. concentrationthe solution was concentrated
  3. washwashed with water, saturated aqueous sodium bicarbonate (2×) and brine
  4. dry with materialthen dried over sodium sulfate
  5. filtrationThe solution was then filtered
  6. concentrationconcentrated

出典と根拠

ORDレコード
ord-3e1222baee6d45589bf84b56df0ac187
出典データセット
uspto-grants-2011_09
特許番号
US08012956B2

反応ノート

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