Phosphorus oxychloride → 2-Chloro-4-(5-chloro-thiophen-2-yl)-6-trifluoromethyl-pyrimidine
反応式
[Cl:1][C:2]1[S:6][C:5]([C:7]2[CH:12]=[C:11]([C:13]([F:16])([F:15])[F:14])[NH:10][C:9](=O)[N:8]=2)=[CH:4][CH:3]=1.O=P(Cl)(Cl)[Cl:20]>>[Cl:20][C:9]1[N:8]=[C:7]([C:5]2[S:6][C:2]([Cl:1])=[CH:3][CH:4]=2)[CH:12]=[C:11]([C:13]([F:16])([F:15])[F:14])[N:10]=1参加物
3
実験手順
The title compound was prepared from 4-(5-chloro-thiophen-2-yl)-6-trifluoromethyl-1H-pyrimidin-2-one (10.0 g, 35.6 mmol) and phosphoroxychloride (50 ml) according to the general procedure I. Obtained as a brown oil (10.4 g, 98%). MS (EI) 298.0, 299.9 [(M)+].
出典と根拠
- ORDレコード
- ord-18d1f992112b402b8696a9137afd3023
- 出典データセット
- uspto-grants-2011_09
- 特許番号
- US08012986B2
反応ノート
読み込み中…