Dimethylamine → [(5-Chloro-1H-indol-3-yl)-(2-fluoro-phenyl)-methyl]-dimethyl-amine

反応式

[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[CH:5]2.[Cl-].[F:12][C:13]1[CH:22]=[CH:21][CH:20]=[CH:19][C:14]=1[CH:15]=[N+:16]([CH3:18])[CH3:17].FC1C=CC=CC=1C=O.CNC>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[CH:15]([N:16]([CH3:18])[CH3:17])[C:14]1[CH:19]=[CH:20][CH:21]=[CH:22][C:13]=1[F:12]

参加物

反応物 4

HCID 674Dimethylamine

HCID 67970o-Fluorobenzaldehyde

HCID 871105-Chloroindole

HCID 21985353(2-Fluoro-benzylidene)-dimethylammonium chloride

生成物 1

HCID 21985292[(5-Chloro-1H-indol-3-yl)-(2-fluoro-phenyl)-methyl]-dimethyl-amine

実験手順

The preparation was carried out in accordance with general synthesis instructions 4 from 5-chloro-1H-indole and (2-fluoro-benzylidene)-dimethylammonium chloride, which had been prepared in accordance with example 44 from 2-fluoro-benzaldehyde and dimethylamine.