Acetic Anhydride → n'-(4-Methoxyphenyl)acetohydrazide

HRID 906478

反応式

HRID 906478 の反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([NH:9][NH2:10])=[CH:5][CH:4]=1.[C:11](OC(=O)C)(=[O:13])[CH3:12]>CCOCC>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([NH:9][NH:10][C:11](=[O:13])[CH3:12])=[CH:5][CH:4]=1

参加物

4

反応物 2

HCID 7918Acetic AnhydrideHCID 77023(4-Methoxyphenyl)hydrazine

生成物 1

HCID 236267n'-(4-Methoxyphenyl)acetohydrazide

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒2 回

反応条件

温度
0 °C

実験手順

10 g of 4-methoxyphenylhydrazine hydrochloride are dissolved in water and then triethylamine is added until the salt has been neutralized. Extraction is carried out with AcOEt and then the extract is evaporated to dryness to produce 8 g of precipitate composed of 4-methoxyphenylhydrazine. This compound is dissolved in 30 ml of ether and then a solution of 13 ml of acetic anhydride dissolved in 30 ml of ether is added dropwise. The mixture is stirred at 0° C. for 15 minutes and then the white precipitate formed is filtered off to produce 7.4 g of the expected compound.

後処理

  1. additionis added dropwise
  2. customthe white precipitate formed
  3. filtrationis filtered off

出典と根拠

ORDレコード
ord-e564ea718d3046edbac9dd5f197dc1c2
出典データセット
uspto-grants-2011_09
特許番号
US08012991B2

関連ノート

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