Phosphorus tribromide → 5-(Bromomethyl)-6-chloro-2H-1,3-benzodioxole

HRID 906490ノート

反応式

HRID 906490 の反応式
[CH2:1]1[O:5][C:4]2[CH:6]=[C:7]([Cl:12])[C:8]([CH2:10]O)=[CH:9][C:3]=2[O:2]1.P(Br)(Br)[Br:14]>C(OCC)C>[Br:14][CH2:10][C:8]1[C:7]([Cl:12])=[CH:6][C:4]2[O:5][CH2:1][O:2][C:3]=2[CH:9]=1

参加物

4

反応物 2

HCID 24614Phosphorus tribromideHCID 7015319(6-Chloro-1,3-benzodioxol-5-yl)methanol

生成物 1

HCID 191052995-(Bromomethyl)-6-chloro-2H-1,3-benzodioxole

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

反応条件

温度
0 °C

実験手順

2.5 g of 6-chloropiperonyl alcohol are dissolved in 80 ml of ethyl ether. The solution is cooled to 0° C. and then 1.9 ml of PBr3 are added. The mixture is stirred at ambient temperature for 18 hours. It is poured onto ice and then extraction is carried out with AcOEt. The organic phase is washed with a saturated NaCl solution. 3.3 g of powder are obtained.

後処理

  1. additionIt is poured onto ice
  2. extractionextraction
  3. washThe organic phase is washed with a saturated NaCl solution

出典と根拠

ORDレコード
ord-758596f7645c4ff1b89bab180b65290d
出典データセット
uspto-grants-2011_09
特許番号
US08012991B2

反応ノート

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