Lithium Chloride → 2-Amino-5-pyrazin-2-yl-4-trifluoromethyl-benzoic acid methyl ester

HRID 906623

反応式

HRID 906623 の反応式
[CH3:1][O:2][C:3](=[O:16])[C:4]1[CH:9]=[C:8](I)[C:7]([C:11]([F:14])([F:13])[F:12])=[CH:6][C:5]=1[NH2:15].C([Sn](CCCC)(CCCC)[C:22]1[CH:27]=[N:26][CH:25]=[CH:24][N:23]=1)CCC.[Li+].[Cl-].C(C1C(C)=CC=C(O)C=1C(C)(C)C)(C)(C)C>O1CCOCC1.C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1>[CH3:1][O:2][C:3](=[O:16])[C:4]1[CH:9]=[C:8]([C:22]2[CH:27]=[N:26][CH:25]=[CH:24][N:23]=2)[C:7]([C:11]([F:14])([F:13])[F:12])=[CH:6][C:5]=1[NH2:15]

参加物

7

反応物 4

HCID 433294Lithium ChlorideHCID 27373162-(Tributylstannyl)pyrazineHCID 3034427Phenol, bis(1,1-dimethylethyl)-4-methyl-HCID 53436880Methyl 2-amino-5-iodo-4-(trifluoromethyl)benzoate

生成物 1

HCID 119657822-Amino-5-pyrazin-2-yl-4-trifluoromethyl-benzoic acid methyl ester収率 38.4%

試薬・触媒・溶媒 2

HCID 178418397HCID 178418397、化合物触媒2 回HCID 312751,4-Dioxane溶媒

反応条件

温度
120 °C

実験手順

A solution containing 2-amino-5-iodo-4-trifluoromethyl-benzoic acid methyl ester (750 mg, 2.17 mmol), 2-tributylstannylpyrazine (1.0 g, 2.7 mmol) and (Ph3P)4Pd (125.6 mg, 0.109 mmol) in dioxane (40 mL) was heated at 120° C. for 17 h. LiCl (276.4 mg, 6.5 mmol) was added and the reaction mixture was refluxed for 1.5 h prior to the addition of di-t-butyl-p-cresol (188 mg, 0.85 mmol) and another portion of (Ph3P)4Pd (251.2 mg, 0.22 mmol). Heating was continued for 16 h, for a total reaction time of 36 h. After cooling to r.t., the solvent was removed in vacuo and the residue was purified by flash chromatography (200 g silica gel, hexanes→EtOAc:hexanes (3:7 to 1:1)). The fractions containing the product were combined and concentrated in vacuo. The resultant oil was further purified by partioning between CH3CN and hexanes. The acetonitrile layer was concentrated in vacuo to furnish the title compound (248 mg, 38%) as a solid. API-ES: m/z 298 [M+H]+, rt 4.18 min.

後処理

  1. temperaturethe reaction mixture was refluxed for 1.5 h
  2. temperatureHeating
  3. temperatureAfter cooling to r.t.
  4. customthe solvent was removed in vacuo
  5. customthe residue was purified by flash chromatography (200 g silica gel, hexanes→EtOAc:hexanes (3:7 to 1:1))
  6. additionThe fractions containing the product
  7. concentrationconcentrated in vacuo
  8. customThe resultant oil was further purified
  9. concentrationThe acetonitrile layer was concentrated in vacuo

出典と根拠

ORDレコード
ord-b3f596651e644fb2bf07956801352832
出典データセット
uspto-grants-2011_09
特許番号
US08012988B2

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