Hydrochloric Acid → 3-[(Pyridin-3-ylmethyl)-amino]-phthalic acid

HRID 906798

反応式

HRID 906798 の反応式
C[O:2][C:3](=[O:22])[C:4]1[C:5](=[C:10]([NH:14][CH2:15][C:16]2[CH:17]=[N:18][CH:19]=[CH:20][CH:21]=2)[CH:11]=[CH:12][CH:13]=1)[C:6]([O:8]C)=[O:7].COCCNC1C=CC=C(C(O)=O)C=1C(O)=O.Cl>>[N:18]1[CH:19]=[CH:20][CH:21]=[C:16]([CH2:15][NH:14][C:10]2[CH:11]=[CH:12][CH:13]=[C:4]([C:3]([OH:22])=[O:2])[C:5]=2[C:6]([OH:8])=[O:7])[CH:17]=1

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 210401363-[(Pyridin-3-ylmethyl)-amino]-phthalic acid dimethyl esterHCID 219885193-(2-Methoxy-ethylamino)-phthalic acid

生成物 1

HCID 219886213-[(Pyridin-3-ylmethyl)-amino]-phthalic acid

実験手順

3-[(Pyridin-3-ylmethyl)-amino]-phthalic acid dimethyl ester (0.91 g, 3.03 mmol) was treated in the same manner as described above for the synthesis of 3-(2-methoxy-ethylamino)-phthalic acid except the pH of crude reaction mixture was adjusted to 2-3 by dropwise addition of concentrated HCl. The solvent was then evaporated in vacuo leaving a dry salt mixture that was used without further purification.

後処理

  1. customreaction mixture
  2. customThe solvent was then evaporated in vacuo
  3. customleaving a dry salt mixture that
  4. customwas used without further purification

出典と根拠

ORDレコード
ord-2601699a997842769bb7b4f0ab1a1fea
出典データセット
uspto-grants-2011_09
特許番号
US08012997B2

関連ノート

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