benzyl (2S,3S)-3-hydroxy-2-isopropyl-3-methylpyrrolidine-1-carboxylate → (2S,3S)-2-isopropyl-3-methylpyrrolidin-3-ol

HRID 906961ノート

反応式

HRID 906961 の反応式
[OH:1][C@@:2]1([CH3:20])[CH2:6][CH2:5][N:4](C(OCC2C=CC=CC=2)=O)[C@H:3]1[CH:17]([CH3:19])[CH3:18]>O>[CH:17]([C@H:3]1[C@@:2]([CH3:20])([OH:1])[CH2:6][CH2:5][NH:4]1)([CH3:19])[CH3:18]

参加物

3

反応物 1

HCID 59273084benzyl (2S,3S)-3-hydroxy-2-isopropyl-3-methylpyrrolidine-1-carboxylate

生成物 1

HCID 59273040(2S,3S)-2-isopropyl-3-methylpyrrolidin-3-ol

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

By an operation in the same manner as in Reference Example 4 and using benzyl (2S,3S)-3-hydroxy-2-isopropyl-3-methylpyrrolidine-1-carboxylate (1.78 g) and 50% water containing −10% Pd/C (0.09 g), the title compound was obtained as a colorless solid (yield: 1.07 g, yield: 89%).

出典と根拠

ORDレコード
ord-ef38d6cc78fc4ae899931dfecc2f47c7
出典データセット
uspto-grants-2011_09
特許番号
US08013008B2

反応ノート

読み込み中…