benzyl (2RS,3SR)-3-hydroxy-2,4,4-trimethylpyrrolidine-1-carboxylate → 2,4,4-Trimethylpyrrolidin-3-OL

HRID 906978ノート

反応式

HRID 906978 の反応式
[OH:1][CH:2]1[C:6]([CH3:8])([CH3:7])[CH2:5][N:4](C(OCC2C=CC=CC=2)=O)[CH:3]1[CH3:19]>CO.[C].[Pd]>[CH3:19][CH:3]1[CH:2]([OH:1])[C:6]([CH3:8])([CH3:7])[CH2:5][NH:4]1

参加物

4

反応物 1

HCID 67390300benzyl (2RS,3SR)-3-hydroxy-2,4,4-trimethylpyrrolidine-1-carboxylate

生成物 1

HCID 673891462,4,4-Trimethylpyrrolidin-3-OL収率 123.9%

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 887Methanol溶媒

実験手順

A suspension (20 mL) of benzyl (2RS,3SR)-3-hydroxy-2,4,4-trimethylpyrrolidine-1-carboxylate (842 mg) and 10% palladium carbon (50% water-containing, 110 mg) in methanol was stirred under a hydrogen atmosphere for 1.5 hr. The reaction mixture was filtered, oxalic acid (144 mg) was added to the filtrate, and the mixture was concentrated under reduced pressure to give the title compound as a colorless solid (yield: 512 mg, yield: 92%).

後処理

  1. filtrationThe reaction mixture was filtered
  2. additionoxalic acid (144 mg) was added to the filtrate
  3. concentrationthe mixture was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-4daf305b659f411fa9683d67ad96b6d0
出典データセット
uspto-grants-2011_09
特許番号
US08013008B2

反応ノート

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