3-Hydroxybenzyl alcohol → {3-[3-(Dimethylamino)propoxy]phenyl}methanol
反応式
C(=O)([O-])[O-].[Cs+].[Cs+].[OH:7][CH2:8][C:9]1[CH:10]=[C:11]([OH:15])[CH:12]=[CH:13][CH:14]=1.Cl.Cl[CH2:18][CH2:19][CH2:20][N:21]([CH3:23])[CH3:22].O>CN(C=O)C>[CH3:22][N:21]([CH3:23])[CH2:20][CH2:19][CH2:18][O:15][C:11]1[CH:10]=[C:9]([CH2:8][OH:7])[CH:14]=[CH:13][CH:12]=1参加物
6
反応条件
- 温度
- 80 °C
実験手順
Cesium carbonate (15.4 g) was added to a solution of 3-hydroxymethyl-phenol (3 g) in DMF (80 mL). To this mixture was added (3-chloro-propyl)-dimethyl-amine hydrochloride (4 g). The mixture was heated at 80° C. for 20 hours then allowed to cool. The reaction mixture was poured into water and extracted with ethyl acetate.
後処理
- temperatureto cool
- extractionextracted with ethyl acetate
出典と根拠
- ORDレコード
- ord-71e4c966cb49405586c71b9ed62f7d0b
- 出典データセット
- uspto-grants-2011_09
- 特許番号
- US08012979B2
反応ノート
読み込み中…