Hydrochloric Acid → Ethyl 2-formyl-1,3-thiazole-4-carboxylate

HRID 907380ノート

反応式

HRID 907380 の反応式
C([O:3][CH:4](OCC)[C:5]1[S:6][CH:7]=[C:8]([C:10]([O:12][CH2:13][CH3:14])=[O:11])[N:9]=1)C.Cl>CC(C)=O>[CH:4]([C:5]1[S:6][CH:7]=[C:8]([C:10]([O:12][CH2:13][CH3:14])=[O:11])[N:9]=1)=[O:3]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 16220290Ethyl 2-(diethoxymethyl)thiazole-4-carboxylate

生成物 1

HCID 11355896Ethyl 2-formyl-1,3-thiazole-4-carboxylate収率 98%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

Ethyl 2-(diethoxymethyl)-1,3-thiazole-4-carboxylate (1.34 g, 5.17 mmol; see step (iv) above) was taken up in acetone (100 mL) and a solution of 1N HCl (12.8 mL) was then added. The solution was refluxed for 45 min and the solvent removed under reduced pressure. The residue was then dissolved in ethyl acetate (40 mL) and extracted with saturated NaHCO3 solution (2×40 mL) and brine (2×40 mL). The organic fraction was then dried (MgSO4), filtered and the solvent removed under reduced pressure to yield the sub-title compound as a light brown solid (0.937 g, 98%).

後処理

  1. temperatureThe solution was refluxed for 45 min
  2. customthe solvent removed under reduced pressure
  3. dissolutionThe residue was then dissolved in ethyl acetate (40 mL)
  4. extractionextracted with saturated NaHCO3 solution (2×40 mL) and brine (2×40 mL)
  5. dry with materialThe organic fraction was then dried (MgSO4)
  6. filtrationfiltered
  7. customthe solvent removed under reduced pressure

出典と根拠

ORDレコード
ord-11a31948ecc140d4be71da7899c446b1
出典データセット
uspto-grants-2011_09
特許番号
US08012967B2

反応ノート

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