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[1-(Cyclopropylcarbamoylhydroxymethyl)cyclopropyl]carbamic acid tert-butyl ester → 2-(1-aminocyclopropyl)-N-cyclopropyl-2-hydroxyacetamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | [1-(Cyclopropylcarbamoylhydroxymethyl)cyclopropyl]carbamic acid tert-butyl ester | HCID 67385903 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 溶媒 | Trifluoroacetic acid | HCID 6422 | — |
| 生成物 | 2-(1-aminocyclopropyl)-N-cyclopropyl-2-hydroxyacetamide | HCID 57562096 | — |
反応手順
A solution of [1-(cyclopropylcarbamoylhydroxymethyl)cyclopropyl]carbamic acid tert-butyl ester in CH2Cl2 (5 mL) and TFA (5 mL) was stirred at room temperature for 2.5 h. The reaction mixture was concentrated and chased with toluene to yield 2-(1-aminocyclopropyl)-N-cyclopropyl-2-hydroxyacetamide.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08013183B2 |
| 出典データセット | uspto-grants-2011_09 |
| ORD ID | ord-52f96089a75549af8ac930f20452d90b |
| 出典メモ | uspto-grants-2011_09 |