Dimethylamine → [[2-(4-Fluoro-phenyl)-1H-indol-3-yl]-(3-phenoxy-phenyl)-methyl]-dimethyl-amine

HRID 9077

反応式

HRID 9077 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[NH:9][C:10]3[C:15]([CH:16]=2)=[CH:14][CH:13]=[CH:12][CH:11]=3)=[CH:4][CH:3]=1.[Cl-].[O:18]([C:25]1[CH:26]=[C:27]([CH:32]=[CH:33][CH:34]=1)[CH:28]=[N+:29]([CH3:31])[CH3:30])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1.O(C1C=C(C=CC=1)C=O)C1C=CC=CC=1.CNC>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[NH:9][C:10]3[C:15]([C:16]=2[CH:28]([N:29]([CH3:31])[CH3:30])[C:27]2[CH:32]=[CH:33][CH:34]=[C:25]([O:18][C:19]4[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=4)[CH:26]=2)=[CH:14][CH:13]=[CH:12][CH:11]=3)=[CH:6][CH:7]=1

参加物

5

反応物 4

HCID 674DimethylamineHCID 382843-PhenoxybenzaldehydeHCID 1366222-(4-Fluorophenyl)indoleHCID 21985375(3-Phenoxy-benzylidene)-dimethylammonium chloride

生成物 1

HCID 69374891[[2-(4-Fluoro-phenyl)-1H-indol-3-yl]-(3-phenoxy-phenyl)-methyl]-dimethyl-amine

実験手順

The preparation was carried out in accordance with general synthesis instructions 4 from 2-(4-fluoro-phenyl)-1H-indole and (3-phenoxy-benzylidene)-dimethylammonium chloride, which had been prepared in accordance with example 44 from 3-phenoxy-benzaldehyde and dimethylamine.

出典と根拠

ORDレコード
ord-8282e8e7abbb474d9be6f23017c76a92
出典データセット
uspto-grants-2006_08
特許番号
US07091220B2

関連ノート

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