Dimethylamine → [[2-(3-Chloro-4-fluoro-phenyl)-1H-indol-3-yl]-(3-phenoxy-phenyl)-methyl]-amine

HRID 9078

反応式

HRID 9078 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[N:10](C)[C:11]3[C:16]([CH:17]=2)=[CH:15][CH:14]=[CH:13][CH:12]=3)[CH:5]=[CH:6][C:7]=1[F:8].[Cl-].[O:20]([C:27]1[CH:28]=[C:29]([CH:34]=[CH:35][CH:36]=1)[CH:30]=[N+:31](C)C)[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1.O(C1C=C(C=CC=1)C=O)C1C=CC=CC=1.CNC>>[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[NH:10][C:11]3[C:16]([C:17]=2[CH:30]([NH2:31])[C:29]2[CH:34]=[CH:35][CH:36]=[C:27]([O:20][C:21]4[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=4)[CH:28]=2)=[CH:15][CH:14]=[CH:13][CH:12]=3)[CH:5]=[CH:6][C:7]=1[F:8]

参加物

5

反応物 4

HCID 674DimethylamineHCID 382843-PhenoxybenzaldehydeHCID 219853262-(3-Chloro-4-fluorophenyl)-1-methylindoleHCID 21985375(3-Phenoxy-benzylidene)-dimethylammonium chloride

生成物 1

HCID 69667101[[2-(3-Chloro-4-fluoro-phenyl)-1H-indol-3-yl]-(3-phenoxy-phenyl)-methyl]-amine

実験手順

The preparation was carried out in accordance with general synthesis instructions 4 from 2-(3-chloro-4-fluoro-phenyl)-methyl-1H-indole and (3-phenoxy-benzylidene)-dimethylammonium chloride, which had been prepared in accordance with example 44 from 3-phenoxy-benzaldehyde and dimethylamine.

出典と根拠

ORDレコード
ord-a3acf54bec8b45b7a82a1278ef642df9
出典データセット
uspto-grants-2006_08
特許番号
US07091220B2

関連ノート

読み込み中…