N-Pyrazinylthiourea → 2-Chloro-4-[4-methyl-2-(pyrazin-2-ylamino)-thiazol-5-yl]-benzenesulfonamide

HRID 908151ノート

反応式

HRID 908151 の反応式
[N:1]1[CH:6]=[CH:5][N:4]=[CH:3][C:2]=1[NH:7][C:8]([NH2:10])=[S:9].Br[CH:12]([C:16]1[CH:21]=[CH:20][C:19]([S:22]([NH2:25])(=[O:24])=[O:23])=[C:18]([Cl:26])[CH:17]=1)[C:13](=O)[CH3:14]>C(O)C>[Cl:26][C:18]1[CH:17]=[C:16]([C:12]2[S:9][C:8]([NH:7][C:2]3[CH:3]=[N:4][CH:5]=[CH:6][N:1]=3)=[N:10][C:13]=2[CH3:14])[CH:21]=[CH:20][C:19]=1[S:22]([NH2:25])(=[O:24])=[O:23]

参加物

4

反応物 2

HCID 2771013N-PyrazinylthioureaHCID 859968284-(1-Bromo-2-oxo-propyl)-2-chloro-benzenesulfonamide

生成物 1

HCID 866062092-Chloro-4-[4-methyl-2-(pyrazin-2-ylamino)-thiazol-5-yl]-benzenesulfonamide

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
60 °C

実験手順

Pyrazin-2-yl-thiourea (Example 1a) (0.047 g, 0.31 mmol) is added to a stirred solution of 4-(1-bromo-2-oxo-propyl)-2-chloro-benzenesulfonamide (0.10 g, 0.31 mmol) in ethanol (5 ml). The solution is heated at 60° C. for 3 hours. The mixture is filtered to remove the precipitate which is washed with methanol and dried. (0.055 g).

後処理

  1. filtrationThe mixture is filtered
  2. customto remove the precipitate which
  3. washis washed with methanol
  4. customdried

出典と根拠

ORDレコード
ord-4ff1e6427203427bb8cdaaff446e3581
出典データセット
uspto-grants-2011_09
特許番号
US08017608B2

反応ノート

読み込み中…