3-Pyridylthiourea → 2-Chloro-4-[4-methyl-2-(pyridin-3-ylamino)-thiazol-5-yl]-benzenesulfonamide

HRID 908152ノート

反応式

HRID 908152 の反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([NH:7][C:8]([NH2:10])=[S:9])[CH:2]=1.Br[CH:12]([C:16]1[CH:21]=[CH:20][C:19]([S:22]([NH2:25])(=[O:24])=[O:23])=[C:18]([Cl:26])[CH:17]=1)[C:13](=O)[CH3:14]>C(O)C>[Cl:26][C:18]1[CH:17]=[C:16]([C:12]2[S:9][C:8]([NH:7][C:3]3[CH:2]=[N:1][CH:6]=[CH:5][CH:4]=3)=[N:10][C:13]=2[CH3:14])[CH:21]=[CH:20][C:19]=1[S:22]([NH2:25])(=[O:24])=[O:23]

参加物

4

反応物 2

HCID 27605153-PyridylthioureaHCID 859968284-(1-Bromo-2-oxo-propyl)-2-chloro-benzenesulfonamide

生成物 1

HCID 866062102-Chloro-4-[4-methyl-2-(pyridin-3-ylamino)-thiazol-5-yl]-benzenesulfonamide収率 16.9%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
60 °C

実験手順

3-Pyridylthiourea (0.047 g, 0.31 mmol) is added to a stirred solution of 4-(1-Bromo-2-oxo-propyl)-2-chloro-benzenesulfonamide (Example 23d) (0.10 g, 0.31 mmol) in ethanol (5 ml). The solution is heated at 60° C. for 3 hours. The solvent is removed and the residue is purified by chromatography on silica eluting with ethyl acetate-hexane to give the title compound (0.020 g).

後処理

  1. customThe solvent is removed
  2. customthe residue is purified by chromatography on silica eluting with ethyl acetate-hexane

出典と根拠

ORDレコード
ord-a499e52bf20f48b8a610812c3f4e8aea
出典データセット
uspto-grants-2011_09
特許番号
US08017608B2

反応ノート

読み込み中…