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Water → 2-Phenylimidazo[1,2-c]pyrimidin-7-amine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Phenacyl bromide | HCID 6259 | — |
| 反応物 | Pyrimidine-4,6-diamine | HCID 79608 | — |
| 反応物 | Sodium Bicarbonate | HCID 516892 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 2-Phenylimidazo[1,2-c]pyrimidin-7-amine | HCID 404051 | — |
反応手順
ω-Bromoacetophenone (9.04 g, 45 mmol) and NaHCO3 (4.30 g, 50 mmol) were added to a solution of 4,6-diaminopyrimidine (5.00 g, 0.45 mmol) in methanol (80 ml), and the mixture was heated to reflux (3 h). Upon cooling, water (40 ml) was added, and the suspension was stirred at r.t. (15 min). The precipitated title compound (5.62 g, 59%) was isolated by filtration, washed with small amounts of water and methanol, and dried under vacuum. MS (m/e)=211.1 [M+H+].
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08017604B2 |
| 出典データセット | uspto-grants-2011_09 |
| ORD ID | ord-977e643049e748a8ae969dd88ddb423f |
| 出典メモ | uspto-grants-2011_09 |