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Hydrochloric Acid → 2-(4-Dimethylamino-4-phenylcyclohexyl)-N-[6-(1H-indol-3-yl)hexyl]acetamide hydrochloride

HRID 908978
ノート
印刷プレビュー

反応式

HRID 908978 の反応式
[CH3:1][N:2]([CH3:34])[C:3]1([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[CH2:8][CH2:7][CH:6]([CH2:9][C:10]([NH:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][C:19]2[C:27]3[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=3)[NH:21][CH:20]=2)=[O:11])[CH2:5][CH2:4]1.[ClH:35]>CC(CC)=O.C(O)C>[ClH:35].[CH3:34][N:2]([CH3:1])[C:3]1([C:28]2[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=2)[CH2:8][CH2:7][CH:6]([CH2:9][C:10]([NH:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][C:19]2[C:27]3[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=3)[NH:21][CH:20]=2)=[O:11])[CH2:5][CH2:4]1
参加物実験手順後処理出典と根拠反応ノート

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 116129622-(4-Dimethylamino-4-phenylcyclohexyl)-N-[6-(1H-indol-3-yl)hexyl]acetamide

生成物 1

HCID 116129612-(4-Dimethylamino-4-phenylcyclohexyl)-N-[6-(1H-indol-3-yl)hexyl]acetamide hydrochloride収率 62%

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 6569Methyl Ethyl Ketone溶媒

実験手順

2-(4-Dimethylamino-4-phenylcyclohexyl)-N-[6-(1H-indol-3-yl)hexyl]acetamide (516 mg, 1.12 mmol) was dissolved in a mixture of ethyl methyl ketone (25 ml) and ethanol (5 ml), and 5 M isopropanolic hydrochloric acid (0.44 ml, 2.2 mmol) was added. After 3 h the reaction mixture was concentrated, ether (15 ml) was added and the mixture was concentrated again. The residue was digested with ether (30 ml). After filtration, the product was obtained as a beige-coloured solid in a yield of 62% (342 mg).

後処理

  1. additionwas added
  2. concentrationAfter 3 h the reaction mixture was concentrated
  3. additionether (15 ml) was added
  4. concentrationthe mixture was concentrated again
  5. filtrationAfter filtration
  6. customthe product was obtained as a beige-coloured solid in a yield of 62% (342 mg)

出典と根拠

ORDレコード
ord-6c8b986d440341758fdbcabc423f99f3
出典データセット
uspto-grants-2011_09
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US08017630B2

反応ノート

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