Methylamine → HCID 178482786、化合物

HRID 909004ノート

反応式

HRID 909004 の反応式
[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=O)=[C:4]([F:10])[CH:3]=1.[CH3:11][NH2:12]>C(Cl)Cl>[Cl:1][C:2]1[CH:9]=[CH:8][C:5](/[CH:6]=[N:12]/[CH3:11])=[C:4]([F:10])[CH:3]=1

参加物

4

反応物 2

HCID 6329MethylamineHCID 27249084-Chloro-2-fluorobenzaldehyde

生成物 1

HCID 178482786HCID 178482786、化合物収率 129%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A mixture of 4-chloro-2-fluoro-benzoaldehyde (Matrix Sci, 3.17 g, 20.0 mmol) and methyl amine (2.0 M in THF, Aldrich, 15 mL, 15.0 mmol) in CH2Cl2 (20 mL) was stirred at rt overnight. The reaction mixture was concentrated and the residue was dried under reduced pressure to afford [[1-(4-chloro-2-fluoro-phenyl)-meth-(E)-ylidene]-methyl-amine (3.32 g, 97.0%) as colorless oil which was used in the next step without further purification.

後処理

  1. concentrationThe reaction mixture was concentrated
  2. customthe residue was dried under reduced pressure

出典と根拠

ORDレコード
ord-1d20a16282d04d55b250733efc63a97b
出典データセット
uspto-grants-2011_09
特許番号
US08017607B2

反応ノート

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