Potassium Hydroxide → rac-(2S,3S,4S)-2-(3-chloro-phenyl)-3-(4-chloro-2-fluoro-phenyl)-4-(2,2-dimethyl-propyl)-pyrrolidine-3-carbonitrile

HRID 909010ノート

反応式

HRID 909010 の反応式
[Cl:1][C:2]1[CH:3]=[C:4](/[CH:8]=[N:9]/[CH3:10])[CH:5]=[CH:6][CH:7]=1.[Cl:11][C:12]1[CH:17]=[CH:16][C:15](/[C:18](=[CH:21]/[CH2:22][C:23]([CH3:26])([CH3:25])[CH3:24])/[C:19]#[N:20])=[C:14]([F:27])[CH:13]=1.[OH-].[K+]>CS(C)=O.O>[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]2[C:18]([C:15]3[CH:16]=[CH:17][C:12]([Cl:11])=[CH:13][C:14]=3[F:27])([C:19]#[N:20])[CH:21]([CH2:22][C:23]([CH3:26])([CH3:25])[CH3:24])[CH2:10][NH:9]2)[CH:5]=[CH:6][CH:7]=1

参加物

6

反応物 3

HCID 14797Potassium HydroxideHCID 58222872(Z)-2-(4-chloro-2-fluoro-phenyl)-5,5-dimethyl-hex-2-enenitrileHCID 178482757HCID 178482757、化合物

生成物 1

HCID 67095616rac-(2S,3S,4S)-2-(3-chloro-phenyl)-3-(4-chloro-2-fluoro-phenyl)-4-(2,2-dimethyl-propyl)-pyrrolidine-3-carbonitrile収率 36.1%

試薬・触媒・溶媒 2

HCID 679Dimethyl Sulfoxide溶媒HCID 962Water溶媒

実験手順

To a solution of [1-(3-chloro-phenyl)-meth-(E)-ylidene]-methyl-amine (0.77 g, 5.00 mmol) and (Z)-2-(4-chloro-2-fluoro-phenyl)-5,5-dimethyl-hex-2-enenitrile (1.72 g, 5.00 mmol) in DMSO (5 mL) was added KOH powder (0.56 g, 10.00 mmol) in one portion. The mixture was stirred at rt overnight. The reaction mixture was diluted with water and extracted with EtOAc three times (3×50 mL). The combined organic layers were washed with water and brine and dried over Na2SO4, and concentrated. The residue was purified by flash column (SiO2, 1%-15% of EtOAc in hexanes) after concentration to give rac-(2S,3S,4S)-2-(3-chloro-phenyl)-3-(4-chloro-2-fluoro-phenyl)-4-(2,2-dimethyl-propyl)-pyrrolidine-3-carbonitrile (0.73 g, 36.1%); HRMS (ES+) m/z Calcd for C22H23Cl2FN2+H [(M+H)+]: 405.1295, found: 405.1292, rac-(2S,3S,4R)-4-(4-chloro-2-fluoro-phenyl)-2-(3-chloro-phenyl)-3-(2,2-dimethyl-propyl)-pyrrolidine (0.0.42 g, 20.8%); HRMS (ES+) m/z Calcd for C22H23Cl2FN2+H [(M+H)+]: 405.1295, found: 405.1294, and (2S,3R,4R)-4-(4-chloro-2-fluoro-phenyl)-2-(3-chloro-phenyl)-3-(2,2-dimethyl-propyl)-pyrrolidine (0.42 g, 20.8%); HRMS (ES+) m/z Calcd for C22H23Cl2FN2+H [(M+H)+]: 405.1295, found: 405.1294.

後処理

  1. extractionextracted with EtOAc three times (3×50 mL)
  2. washThe combined organic layers were washed with water and brine
  3. dry with materialdried over Na2SO4
  4. concentrationconcentrated
  5. customThe residue was purified by flash column (SiO2, 1%-15% of EtOAc in hexanes)
  6. concentrationafter concentration

出典と根拠

ORDレコード
ord-f9575774c88b4ca69df0166e271fdb1a
出典データセット
uspto-grants-2011_09
特許番号
US08017607B2

反応ノート

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