Hydrochloric Acid → HCID 178456373、化合物
反応式
C(OC(=O)[NH:7][C@H:8]1[CH2:13][CH2:12][C@H:11]([C:14]([N:16]2[CH2:21][CH2:20][N:19]([CH:22]([CH3:24])[CH3:23])[CH2:18][CH2:17]2)=[O:15])[CH2:10][CH2:9]1)(C)(C)C.[ClH:26]>O1CCOCC1>[ClH:26].[ClH:26].[NH2:7][C@H:8]1[CH2:13][CH2:12][C@H:11]([C:14]([N:16]2[CH2:17][CH2:18][N:19]([CH:22]([CH3:24])[CH3:23])[CH2:20][CH2:21]2)=[O:15])[CH2:10][CH2:9]1参加物
4
反応条件
- 温度
- 50 °C
実験手順
A mixture of 4.56 g (12 mmol) [trans-4-(4-isopropyl-piperazine-1-carbonyl)-cyclohexyl]-carbamic acid tert-butyl ester and 29 mL 4N HCl in dioxane was stirred for 6 h at 50° C. evaporated to dryness and used without further purification in the subsequent step. MS (m/e): 254.1 (MH+).
後処理
- customevaporated to dryness
- customused without further purification in the subsequent step
出典と根拠
- ORDレコード
- ord-cc071450fa2540b0a2b9884ec074b78e
- 出典データセット
- uspto-grants-2011_09
- 特許番号
- US08017773B2
反応ノート
読み込み中…