tert-Butyl methyl ether → 1,2-Benzenediol, 4-(3-hydroxypropyl)-

HRID 909697

反応式

HRID 909697 の反応式
O[CH2:2][C:3]([C:5]1[CH:6]=[C:7]([OH:12])[C:8](=[CH:10][CH:11]=1)[OH:9])=O.[CH3:13][O:14]C(C)(C)C>>[CH:11]1[C:5]([CH2:3][CH2:2][CH2:13][OH:14])=[CH:6][C:7]([OH:12])=[C:8]([OH:9])[CH:10]=1

参加物

3

反応物 2

HCID 15413tert-Butyl methyl etherHCID 221344442-Hydroxy-3′,4′-dihydroxyacetophenone

生成物 1

HCID 112174641,2-Benzenediol, 4-(3-hydroxypropyl)-

反応条件

温度
40 °C

実験手順

A special house made pressure reactor, a 50 ml 10 bar glass reactor with steel mantle and a magnetic stirring bar, was charged with catalyst, 4-hydroxyacetyl-catechol (produced according to Example 2) and t-butyl methyl ether. The reactor was evacuated and filled with hydrogen. Hydrogenation was started by stirring at 5 bar hydrogen pressure while heating to 40° C. By the end of the reaction the hydrogen was replaced by air, the slurry was filtered, the catalyst was washed with ethyl acetate. After evaporation of the solvents and drying at 1 mbar the product was analyzed quantitatively. The details of some reactions and the results are shown in Table 1.

後処理

  1. customThe reactor was evacuated
  2. additionfilled with hydrogen
  3. customBy the end of the reaction the hydrogen
  4. filtrationthe slurry was filtered
  5. washthe catalyst was washed with ethyl acetate
  6. customAfter evaporation of the solvents
  7. customdrying at 1 mbar the product

出典と根拠

ORDレコード
ord-3c54dba0bde4486c8305ae18deb44e6c
出典データセット
uspto-grants-2011_09
特許番号
US08017815B2

関連ノート

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