Formic Acid → 4-Methylbenzimidazole

HRID 909843

反応式

HRID 909843 の反応式
[NH2:1][C:2]1[C:7]([NH2:8])=[CH:6][CH:5]=[CH:4][C:3]=1[CH3:9].Cl.[OH-].[NH4+].[CH:13](O)=O>>[CH3:9][C:3]1[C:2]2[N:1]=[CH:13][NH:8][C:7]=2[CH:6]=[CH:5][CH:4]=1

参加物

5

反応物 4

HCID 284Formic AcidHCID 313Hydrochloric AcidHCID 14923Ammonium HydroxideHCID 175932,3-Diaminotoluene

生成物 1

HCID 15193414-Methylbenzimidazole

実験手順

To a flask were added 2.0 g 2,3-diaminotoluene, 1.0 g 90% formic acid and 30 ml 5M hydrochloric acid and the mixture was heated to 90 C under nitrogen for 4 hours. After cooling to 22 C, the mixture was basified with aqueous ammonium hydroxide and the product was removed by filtration and washed with water. The product was purified by column chromatography using pure ethyl acetate resulting in 1.0 g brown solid.

後処理

  1. temperaturethe mixture was heated to 90 C under nitrogen for 4 hours
  2. temperatureAfter cooling to 22 C
  3. customthe product was removed by filtration
  4. washwashed with water
  5. customThe product was purified by column chromatography

出典と根拠

ORDレコード
ord-e611cfd05cd3458aa1fe95824f2e64bd
出典データセット
uspto-grants-2011_09
特許番号
US08018639B2

関連ノート

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