{[2-(Tert-butoxycarbonylamino)-ethyl]-methyl-amino}-acetic acid benzyl ester → HCID 22270159、化合物

HRID 910001

反応式

HRID 910001 の反応式
C([O:8][C:9](=[O:23])[CH2:10][N:11]([CH2:13][CH2:14][NH:15][C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])[CH3:12])C1C=CC=CC=1>CO.[C].[Pd]>[C:19]([O:18][C:16]([NH:15][CH2:14][CH2:13][N:11]([CH2:10][C:9]([OH:23])=[O:8])[CH3:12])=[O:17])([CH3:22])([CH3:20])[CH3:21]

参加物

4

反応物 1

HCID 59650730{[2-(Tert-butoxycarbonylamino)-ethyl]-methyl-amino}-acetic acid benzyl ester

生成物 1

HCID 22270159HCID 22270159、化合物収率 100%

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 887Methanol溶媒

実験手順

162 mg (0.5 mmol) of {[2-(tert-butoxycarbonylamino)-ethyl]-methyl-amino}-acetic acid benzyl ester prepared in Process 3-A was dissolved in methanol (5 mL), and then 5% palladium-carbon was added to it, and this was stirred under a hydrogen atmosphere at room temperature for one hour. After filtering off the insoluble material, the filtrate was concentrated to yield 116 mg (100%) of {[2-(tert-butoxycarbonylamino)-ethyl]-methyl-amino}-acetic acid as a colorless viscous oil.

後処理

  1. filtrationAfter filtering off the insoluble material
  2. concentrationthe filtrate was concentrated

出典と根拠

ORDレコード
ord-8f02cee8e22f4c1283d519cfb9566590
出典データセット
uspto-grants-2011_09
特許番号
US08022047B2

関連ノート

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