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Imidazole → 3-tert-Butyldimethylsilyloxy Pregnenolone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Imidazole | HCID 795 | — |
| 反応物 | Pregnenolone | HCID 8955 | — |
| 反応物 | tert-Butyldimethylsilyl trifluoromethanesulphonate | HCID 123564 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 3-tert-Butyldimethylsilyloxy Pregnenolone | HCID 10884505 | — |
反応手順
Imidazole (ImH) can be added to a solution of pregnenolone (compound 3, see Scheme 1) in anhydrous dimethylformamide (DMF). Tert-butyldimethylsilyltrifluoromethanesulfonate can then be added to the solution. The reaction product can be purified to obtain compound 4, 1-((3S,8S,9S,10R,13S,14S,17S)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-3-[(1,1-dimethylethyl)dimethylsilyloxy]-10,13-dimethyl-1H-cyclopenta[α]phenanthren-17-yl) ethanone, as shown in Scheme 2.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08022052B2 |
| 出典データセット | uspto-grants-2011_09 |
| ORD ID | ord-3f85b035e8f748f09b57c7667340d385 |
| 出典メモ | uspto-grants-2011_09 |