Methyl 2-(3-phenoxypropenyl)benzoate → Methyl 2-(3-phenoxypropyl)benzoate

HRID 910166ノート

反応式

HRID 910166 の反応式
[O:1]([CH2:8][CH:9]=[CH:10][C:11]1[CH:20]=[CH:19][CH:18]=[CH:17][C:12]=1[C:13]([O:15][CH3:16])=[O:14])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>CO.[C].[Pd]>[O:1]([CH2:8][CH2:9][CH2:10][C:11]1[CH:20]=[CH:19][CH:18]=[CH:17][C:12]=1[C:13]([O:15][CH3:16])=[O:14])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

4

反応物 1

HCID 67414986Methyl 2-(3-phenoxypropenyl)benzoate

生成物 1

HCID 67413057Methyl 2-(3-phenoxypropyl)benzoate収率 55%

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 887Methanol溶媒

実験手順

The thus-obtained methyl 2-(3-phenoxypropenyl)benzoate (0.261 g, 0.972 mmol) was dissolved in methanol (6 ml), 10% palladium carbon (0.022 g) was added, and a hydrogenation reaction was performed at room temperature for 24 hr. The reaction mixture was filtered through celite, the filtrate was concentrated under reduced pressure, and the obtained residue was purified by silica gel column chromatography (hexane:ethyl acetate) to give methyl 2-(3-phenoxypropyl)benzoate (0.144 g, 0.533 mmol, yield 55%).

後処理

  1. customa hydrogenation reaction
  2. filtrationThe reaction mixture was filtered through celite
  3. concentrationthe filtrate was concentrated under reduced pressure
  4. customthe obtained residue was purified by silica gel column chromatography (hexane:ethyl acetate)

出典と根拠

ORDレコード
ord-81897f41f7554283830d72136a92baea
出典データセット
uspto-grants-2011_09
特許番号
US08022072B2

反応ノート

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