Bromine → 6-Bromothieno[2,3-d]pyrimidin-4(1H)-one
反応式
[N:1]1[C:6]2[S:7][CH:8]=[CH:9][C:5]=2[C:4](=[O:10])[NH:3][CH:2]=1.[Br:11]Br>C(O)(=O)C>[Br:11][C:8]1[S:7][C:6]2[N:1]=[CH:2][NH:3][C:4](=[O:10])[C:5]=2[CH:9]=1参加物
4
実験手順
A suspension of 3H-thieno[2,3-d]pyrimidin-4-one (7.68 g, 0.056 mol) in glacial acetic acid (75 ml) was treated with bromine (7.5 ml) and stirred at ambient temperature for 4 hours. The resulting solid was collected by filtration, washed with water and dried in vacuo to give 6-bromo-3H-thieno[2,3-d]pyrimidin-4-one as a light brown solid (11.64 g), which was used without further purification.
後処理
- filtrationThe resulting solid was collected by filtration
- washwashed with water
- customdried in vacuo
出典と根拠
- ORDレコード
- ord-a28f81e20c5c4d80bff95d375f4f9343
- 出典データセット
- uspto-grants-2011_09
- 特許番号
- US08022076B2
反応ノート
読み込み中…