Acetic Acid → HCID 67382248、化合物

HRID 910203ノート

反応式

HRID 910203 の反応式
[CH3:1][C:2]1[S:12][C:5]2[NH:6][C:7](=[O:11])[NH:8][C:9](=[O:10])[C:4]=2[CH:3]=1.C(O)(=O)C.[Br:17]Br>O>[Br:17][C:3]1[C:4]2[C:9](=[O:10])[NH:8][C:7](=[O:11])[NH:6][C:5]=2[S:12][C:2]=1[CH3:1]

参加物

5

反応物 3

HCID 176Acetic AcidHCID 24408BromineHCID 127242076-Methylthieno[2,3-d]pyrimidine-2,4(1H,3H)-dione

生成物 1

HCID 67382248HCID 67382248、化合物

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A brown glass round-bottom flask was charged with 6-methyl-1H-thieno[2,3-d]pyrimidine-2,4-dione (2.70 g, 14.8 mmol) and glacial acetic acid (30 ml). Bromine (2.70 ml) was added and the mixture stirred at ambient temperature for 4 hours. The resultant mixture was diluted with water (30 ml) and the solid was collected by filtration, washed thoroughly with water and then dried in vacuo to give 5-bromo-6-methyl-1H-thieno[2,3-d]pyrimidine-2,4-dione as a brown solid (2.43 g), which was used without further purification.

後処理

  1. filtrationthe solid was collected by filtration
  2. washwashed thoroughly with water
  3. customdried in vacuo

出典と根拠

ORDレコード
ord-cfa9fdeba9e34fe7ad6cdc06a7a0cf0c
出典データセット
uspto-grants-2011_09
特許番号
US08022076B2

反応ノート

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